2024 Author: Josephine Shorter | [email protected]. Last modified: 2023-12-16 21:43
Intoxication of the body with drugs
Medicines were invented many years ago to relieve various human suffering. If used ineptly and improperly, they can cause severe intoxication, and even death. Initially, drugs are prescribed for pain relief, insomnia, and other health problems, but sometimes they provoke an irresistible addiction. In this case, any prescribed treatment not only does not prolong a person's life, but significantly shortens it.
It should be noted that sometimes completely harmless preparations of iron or other vitamins can provoke poisoning and overdose. Drug intoxication is a fairly common clinical situation of the acute type. It occurs quite often, since a wide variety of pharmaceuticals can be seriously overdosed. First of all, it is worth noting such drugs that cause addiction (opiates, hypnotics, sedatives, hallucinogens and stimulants. Also, cases of intoxication after taking antidepressants and antipsychotics are not uncommon.
How do drug intoxication of the body manifest?
The main symptom should be noted severe headaches. As a rule, several serious pathogenetic mechanisms of the development of such a factor are distinguished. If the patient has a slight predisposition to severe headaches or when the headaches are compensated, often taking pharmaceuticals causes a breakdown of the compensatory capabilities. These drugs often include hormonal and oral contraceptives, as well as other sympathomimetics.
When severe headaches occur with vasodilation, this effect is usually caused by the intake of caffeine, nitrates, nifedipine, pseudoephedrine, hydralazine, and bronchodilators. In some cases, headaches are part of another syndrome - withdrawal of analgesics, ergotamines, NSAIDs, caffeine, or narcotic drugs.
The development of benign intracranial hypertension and aseptic meningitis can be provoked by such modern drugs as ibuprofen, methotrexate, or intradural administration of any epidural anesthetic by mistake. In addition, some antibiotics, oral contraceptives, and corticosteroids can be included.
Personal and behavioral changes, as well as cognitive impairment from taking numerous drugs are due to direct effects on the human nervous system. Such serious disorders are mediated by various lesions of the kidney or liver. As a rule, the severity of these symptoms has a specific dose-dependent character.
Many chemotherapeutic agents, such as methotrexate or cytosine-arabinoside, often lead to the development of severe intoxication of the body with toxic brain lesions. This condition is otherwise called leukoencephalopathy. the main signs of this syndrome are various mental disorders, which usually progress in the form of depression of consciousness, after which the risk of death is high.
In addition, the simultaneous irradiation of the brain with this dangerous therapy or prolonged interthecal administration of drugs significantly increase the risk of complications.
Childhood drug poisoning occurs more often than intoxication in adults. taking certain drugs in higher dosages or uncontrolled use of several types of drugs by a child in the absence of adults are the most common cases. Targeted drug poisoning during adolescence with suicide is much less common. These commonly used drugs include benzodiazepines, analgesics, potent anticholinergics, tricyclic antidepressants, and antihistamines and hypnotics.
How to solve the problem of drug intoxication in the body?
With the prescribed treatment, which causes severe headaches, timely withdrawal of a particular drug is indicated. With the development of benign intracranial hypertension or in the event of aseptic meningitis, additional therapy is prescribed in a hospital under the supervision of doctors. As a rule, a mandatory consultation with a neurologist is recommended.
In this case, the accompanying neurological symptomatology, which is expressed by the absence of positive dynamics due to the withdrawal of a particular drug, presumably causing significant headaches, is also of important diagnostic value.
When it is not possible to stop taking or change the medication, then some symptomatic treatment is necessary. To resolve this issue, consultations of narrowly focused highly qualified specialists are required. A simple change in the dosage regimen of this pharmaceutical is usually helpful in reducing the severity of headaches.
Article author: Mochalov Pavel Alexandrovich | d. m. n. therapist
Education: Moscow Medical Institute. IM Sechenov, specialty - "General Medicine" in 1991, in 1993 "Occupational Diseases", in 1996 "Therapy".
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