A Revolution In Immunology: A New Generation Of Immunomodulatory Agents

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Video: A Revolution In Immunology: A New Generation Of Immunomodulatory Agents

Video: A Revolution In Immunology: A New Generation Of Immunomodulatory Agents
Video: Pharmacology of Blood - Immunomodulatory Agents 2024, March
A Revolution In Immunology: A New Generation Of Immunomodulatory Agents
A Revolution In Immunology: A New Generation Of Immunomodulatory Agents
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A new generation of immunomodulatory agents

Transfer factors
Transfer factors

Transfer factors - the so-called signaling immunoactive molecules - were discovered in 1949 by the American scientist Lawrence, and since then hundreds of scientific studies in the field of immunology have been carried out on the basis of this important discovery. The result of the work of scientists around the world has become a medical product, the principle of which is unique: Transfer Factor proves that immunity donation is the same reality as blood donation.

The basis of the drug is the transfer factors of the same name, which are peptides consisting of forty-four amino acids. These peptides differ from previously known antibodies by a significantly lower molecular weight - from 3.5 to 10 thousand daltons, which facilitates their integration into the immune system. The main feature of transfer factors is that they act effectively, regardless of whether the donor and recipient are representatives of the same biological species. In other words, transfer factors derived from any mammal can help humans cope with disease.

Content:

  • How do transfer factors work?
  • Three active fractions of transfer factors
  • Unique advantages of transfer factors
  • The history of drug development
  • Scientific test results
  • Composition and form of release
  • Reviews of doctors about the drug Transfer Factor

How do transfer factors work?

For more than half a century of scientific research in this area, it has been established that donor transfer factors regulate the activity of three types of immune cells in the human body:

  • T-killers;
  • T-suppressors;
  • Macrophages.

Transfer Factor drug, produced by the American company "4Life Research", is effective in a number of diseases associated with disorders of the immune system. Moreover, it is absolutely safe and hypoallergenic, since it contains only active cytokine fractions similar to human leukocyte cytokines. All potential allergens (casein, lactoglobulin) are completely removed from the preparation.

In our country, this medicine was thoroughly investigated by the academician of the Russian Academy of Medical Sciences A. A. Vorobyov. The research results look promising: Transfer Factor does not give any side effects, is not addictive, has no contraindications, and at the same time has a positive effect in the treatment of any diseases of the immune system. It can be safely recommended to patients of any age and at any stage of the disease. No undesirable effects from the combination of Transfer Factors with other drugs have also been identified.

Three active fractions of transfer factors

If you try to give the Transfer Factor the most accurate definition, then it is better to call it not an immunomodulator, not an immunosuppressant, but an immunocorretor. The fact is that this drug is able to both activate and weaken the immune response in the human body, depending on what effect is really needed. As you know, most diseases develop either because the immune system cannot cope with them, or because it "overdid it" (autoimmune diseases).

A Transfer Factor contains three active fractions, thanks to which the desired result is always achieved:

  • Inductors;
  • Suppressors;
  • Antigen-specific transfer factors.

The first type of components is responsible for the speed at which the immune response is triggered, that is, it brings our body into a state of alert, so that when a threat arises, all forces are thrown to fight it without delay. Suppressors soothe the cleared immunity and force it to "withdraw troops from the battlefield" in time, because if this is not done, another threat can take advantage of the absence of a regular army and strike unexpectedly elsewhere. Finally, the antigen-specific transfer factors that give the drug its name are a ready-to-use set of cytokines and antigens that can cope with almost any infection.

Transfer Factor allows a person to do the seemingly impossible - to take control of the immune system into their own hands. The active components of this drug, on the one hand, provide an adequate response of immune cells to an external threat, and on the other hand, they accelerate the process of infection recognition and presentation to all immunocompetent cells. The sooner our T-lymphocytes get to know foreign antigens, the faster antibodies to them will be produced, and the body's fight against the disease will begin.

Unique advantages of transfer factors

Transfer factors
Transfer factors

Transfer factors have a number of advantages over other active substances used by medicine to regulate the immune system:

  • The widest spectrum of action and the largest list of treatable diseases;
  • Complete absence of contraindications and side effects;
  • Enhancing the activity of macrophage cells responsible for recognizing hostile antibodies and accelerating macrophage reactions;
  • A whole set of antigens and cytokines already ready for work;
  • Prevention of disproportionate and inappropriate responses of the immune system and the fight against existing failures.

An example of how macrophages work is Peyer's patches located on the inner surface of the human intestine. There, macrophages are constantly synthesized, thanks to which our body receives protection from infections that come with food. During digestion, macrophages recognize and destroy harmful bacteria, and also transmit information about them (a special protein code) to T-lymphocytes. These, in turn, trigger the production of antibodies so that the body acquires a weapon against this threat in the future. So the Transfer Factor drug, among other things, activates macrophages, accelerates the process of recognizing and destroying an infection and preparing immunity for a possible future meeting with it.

The history of drug development

We receive the first transfer factors in infancy with mother's milk. This is the natural donation of immunity. Any obstetrician-gynecologist strives to give the woman in labor the opportunity to attach the baby to the breast immediately after childbirth, since the hormones and immune fractions contained in colostrum are priceless. A mother can provide this help to her child only from the first days after birth, and if the opportunity is missed, it will never be possible to make up for the loss.

Colostrum contains a ready-made set of antibodies to all infections that a mother has encountered in her life. And this allows us to hope that the baby will be protected from most potential threats. Even if he, fortunately, does not face them immediately, his immune system will become familiar with possible enemies and will be able to cope with many diseases in the future. The adage “it's better to learn from the mistakes of others than to fill your own bumps” may be the best leitmotif of this process.

For more than 60 years man has known about transfer factors, and during this time about forty million dollars have been spent on their comprehensive research. About three thousand scientific papers have been published by scientists around the world, and eleven international symposia have already taken place. But this is not the limit - research continues, so it is hoped that in the future even more benefits will be derived from this discovery.

It would be a mistake to believe that transfer factors are relevant only in cases of weakened immunity or autoimmune diseases. Try to name a pathology in the development or fight against which immune cells would not be involved in one way or another. It is unlikely that you will succeed. Everything from allergies to oncology, one way or another, lends itself to transfer factors. This means that the study of these substances will be relevant for many years to come.

At the last international symposium on transfer factors, scientists from several countries presented the results of large-scale studies, including those carried out using the American drug of the same name Transfer Factor. The list of diseases in the treatment of which this medicine has shown excellent results is very impressive: malignant tumors, allergies, bronchial asthma, rheumatoid arthritis, multiple sclerosis and many others.

It is also noteworthy that Transfer Factor is effective at any stage of the disease - it helped both people with minor health problems and the seriously ill, bedridden and almost devoid of hope for recovery. The safety and versatility of the drug was especially noted - not a single case of side effects or adverse reactions to the combined use of Transfer Factor with other drugs (taktivin, immunal, myelopid, thymogen) was registered.

Scientific test results

4Life Research produces two types of immunocorrecting drugs: Transfer Factor and Transfer Factor Plus (with the addition of adaptogens). Tests have shown that the first drug increases the activity of killer T cells by about 103%, and the second by as much as 243%. No other immunomodulator known to science gives such results.

At the Russian Cancer Center, Professors E. O. Khalturina and M. V. Kiselev also tested American drugs. They studied the effect of transfer factors on donor blood. It was found that the drugs significantly enhance the cytotoxic and antitumor activity of mononuclear immune cells, and the drugs work best not alone, but together, either in a 70:30 or 50:50 ratio of Transfer Factor and Transfer Factor plus. The combination of drugs allows you to activate the work of immune cells not by 18%, but by 80-99%. For comparison, interleukin-2, a unique substance produced by our body, has the same cytotoxic and antitumor effect, but, alas, in insufficient quantities to defeat cancer.

Composition and form of release

Transfer Factor preparation is synthesized from bovine colostrum, and Transfer Factor plus, in addition, contains a number of additional active components:

  • Zinc monomethionine;
  • Soybean phytosterols;
  • Inositol Hexaphosphate;
  • D beta glucan;
  • Cordyceps sinensis;
  • Lemon, aloe and oat extract;
  • Olive leaves;
  • Mushrooms Aqaricus blazeii, Grifolea frondosa, Lentinus edodes.

These components enhance the effect of the drug and add restorative properties to it. Both drugs are available in the form of gelatin capsules packed in plastic sealed containers.

Reviews of doctors about the drug Transfer Factor

Reviews
Reviews

Victor Alexandrovich Tutelyan, Professor, Doctor of Medical Sciences, Member of the Russian Academy of Medical Sciences, Director of the Institute of Nutrition:

Transfer Factor is one of the most important and promising developments in the field of medicine over the past half century.

Alexey Ivanovich Egorov, infectious disease doctor, candidate of medical sciences:

For many years I myself suffered from allergic rhinitis, chronic sinusitis, and complained of a reduced sense of smell. Having learned about the Transfer Factor drug, I decided to try it on myself, because I understood perfectly well that my sores are of an allergic nature, which means they should be treatable with transfer factors.

I cannot say that the drug acts quickly. It took me about three months to achieve a lasting positive effect, but now I feel good - nasal breathing is free, sleep is sound, there was no recurrence of sinusitis, and my sense of smell returned. It's such a joy to smell again!

In addition, I can say that last year, while on vacation, I climbed the summit of Elbrus in the company of a friend who had three transmural myocardial infarction. How did he decide on such an adventure? On my advice, I have been taking Transfer Factor for several months!

Alexey Yaroslavovich Chizhov, Professor, Doctor of Medical Sciences, Honored Scientist of the Russian Federation:

I have been suffering from hypertension for a long time, and I have not tried what drugs over the years. On the recommendation of a colleague, I purchased a Transfer Factor. There was little hope of success, because usually the more hype about a drug, the less useful it is. I drink one month - the result is zero, I drink two months - the result is zero. I wanted to give up this venture, but a colleague asked me:

- Listen, how long have you been on your prescribed high blood pressure medications?

- Well, for six months … And some for years.

- And what, help?

- Not all at once and not all. (As a doctor, I understand that hypertensive patients will have to drink such drugs all their lives)

- Well, you want Transfer Factor to give you fantastic results in a couple of months.

I continued taking the drug, and after about nine months, the pressure gradually returned to normal! Now my upper blood pressure never rises above 140, moreover, I do not drink any other drugs.

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The author of the article: Kuzmina Vera Valerievna | Endocrinologist, nutritionist

Education: Diploma of the Russian State Medical University named after NI Pirogov with a degree in General Medicine (2004). Residency at Moscow State University of Medicine and Dentistry, diploma in Endocrinology (2006).

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